Warkmycin, a novel angucycline antibiotic produced by Streptomyces sp. Acta 2930

被引：0

作者：

Soleiman E Helaly

Michael Goodfellow

Heidi Zinecker

Johannes F Imhoff

Roderich D Süssmuth

Hans-Peter Fiedler

机构：

[1] Institut für Chemie,Department of Chemistry

[2] FG Organische Chemie,undefined

[3] Technische Universität Berlin,undefined

[4] Faculty of Science,undefined

[5] Aswan University,undefined

[6] School of Biology,undefined

[7] University of Newcastle,undefined

[8] Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz-Zentrum für Ozeanforschung Kiel,undefined

[9] Mikrobiologisches Institut,undefined

[10] Universität Tübingen,undefined

[11] 6Current address: Pharmazeutisches Institut,undefined

[12] Universität Bonn,undefined

[13] Germany.,undefined

来源：

The Journal of Antibiotics | 2013年 / 66卷

关键词：

angucycline antibiotic; antibacterial; antitumor;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A novel angucycline-type antibiotic, warkmycin, was isolated from the culture filtrate of Streptomyces strain Acta 2930. Its chemical structure was elucidated by HR-MS, one-dimensional and 2D NMR experiments. The compound inhibits the growth of Gram-positive bacteria and shows a strong antiproliferative activity against mouse fibroblast cell line NIH-3T3 and human cancer cell lines HepG2 and HT29.

引用

页码：669 / 674

页数：5

共 50 条

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[J]. JOURNAL OF ANTIBIOTICS, 2013, 66 (11): : 669 - 674
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