Decision tree–driven tandem mass spectrometry for shotgun proteomics

被引：0
|
作者：
Danielle L Swaney
Graeme C McAlister
Joshua J Coon
机构：
[1] 1101 University Avenue,Department of Chemistry
[2] University of Wisconsin,Department of Biomolecular Chemistry
[3] Madison,undefined
[4] Wisconsin 53706,undefined
[5] USA.,undefined
[6] 1300 University Avenue,undefined
[7] University of Wisconsin,undefined
[8] Madison,undefined
[9] Wisconsin 53706,undefined
[10] USA.,undefined
来源：
Nature Methods | 2008年 / 5卷
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摘要：
The two major mechanisms for peptide fragmentation by mass spectrometry, collision-activated dissociation (CAD) or a newer method, electron transfer dissociation (ETD), display different efficacies for different peptide chemistries. A decision tree algorithm, which can be embedded into instruments with both CAD and ETD capabilities, selects the optimal fragmentation method to improve the chances of successful peptide identification.
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页码：959 / 964
页数：5
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