Metabolomic screening and star pattern recognition by urinary amino acid profile analysis from bladder cancer patients

被引：0
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作者：
Jeong-Whun Kim
Gwang Lee
Seung-Min Moon
Myung-June Park
Sung Kyu Hong
Young-Hwan Ahn
Kyoung-Rae Kim
Man-Jeong Paik
机构：
[1] Seoul National University Bundang Hospital,Department of Otorhinolaryngolog
[2] Research Center for Sensory Organs in Seoul National University Medical Research Center,Metabolomic Analysis Laboratory, Institute for Neuroregeneration and Stem Cell Research
[3] School of Medicine,Department of Molecular Science and Technology
[4] Ajou University,Brain Disease Research Center
[5] School of Medicine,Department of Chemical Engineering
[6] Ajou University,Department of Urology
[7] School of Medicine,Department of Neurosurgery
[8] Ajou University,Biometabolite Analysis Laboratory, College of Pharmacy
[9] Ajou University,undefined
[10] Seoul National University Bundang Hospital,undefined
[11] School of Medicine,undefined
[12] Ajou University,undefined
[13] Sungkyunkwan University,undefined
来源：
Metabolomics | 2010年 / 6卷
关键词：
Metabolomic analysis; Bladder cancer; Urinary amino acids (AAs); Gas chromatography–mass spectrometry (GC–MS); Star pattern recognition;
D O I：
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中图分类号：
学科分类号：
摘要：
Metabolomic analysis of urinary amino acids (AAs) from patients with bladder cancer was performed by gas chromatography–mass spectrometry. The β-aminoisobutyric acid (P < 0.05) and pyroglutamic acid (P < 0.03) levels among 21 AAs had relatively low P-values in the cancer group. The distorted star pattern of the cancer group was different from the heneicosagonal shape of the control mean. The present metabolomic screening combined with star pattern recognition method as clinical monitoring tool might be useful for the visual discrimination of bladder cancer group from normal group.
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页码：202 / 206
页数：4
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