Role of Copper Dyshomeostasis in the Pathogenesis of Parkinson’s Disease

被引：0
|
作者：
M. N. Karpenko
E. Yu. Ilyicheva
Z. M. Muruzheva
I. V. Milyukhina
Yu. A. Orlov
L.V. Puchkova
机构：
[1] Institute of Experimental Medicine,
[2] St. Petersburg National Research University of Information Technologies,undefined
[3] Mechanics,undefined
[4] and Optics (ITMO University),undefined
[5] Peter the Great St. Petersburg Polytechnic University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2018年 / 164卷
关键词：
Parkinson’s disease; copper imbalance; ceruloplasmin; labile copper atoms of ceruloplasmin; Cu/Zn-superoxide dismutase 3;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson’s disease in comparison with the corresponding parameters in age-matched healthy individuals, but the ratio of apoceruloplasmin to holoceruloplasmin in patients with Parkinson’s disease was similar in both groups. Treatment of blood serum with Helex 100, a high-affinity copper chelator, revealed reduced content of labile copper atoms per ceruloplasmin molecule in patients with Parkinson’s disease in comparison with that in healthy controls. The mechanism underlying impaired metabolic incorporation of labile copper atoms into CP molecule is discussed as a possible cause of copper dyshomeostasis associated with Parkinson’s disease.
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页码：596 / 600
页数：4
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