Effects of intravenous and local anesthetic agents on ω-conotoxin MVIIA binding to rat cerebrocortex

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作者
Kazuyoshi Hirota
David G. Lambert
机构
[1] Leicester Royal Infirmary,From the University Department of Anaesthesia and Pain Management
[2] University of Hirosaki School of Medicine,Department of Anesthesiology
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关键词
Dexmedetomidine; Etomidate; Procaine; Local Anesthetic Agent; Barbituric Acid;
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摘要
Purpose: The cellular target site(s) for anesthetic action remain controversial. In this study we have examined any interaction of iv anesthetics (thiopental, pentobarbital, ketamine, etomidate, propofol, alphaxalone), local anesthetics (lidocaine, prilocaine, procaine and tetracaine), and the non anesthetic barbiturate, barbituric acid with the ω-conotoxin MVIIA binding site on N-type voltage sensitive Ca2+ channels in rat cerebrocortical membranes.
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页码:467 / 470
页数:3
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