High oxygen concentrations inhibit Acanthamoeba spp.

被引：0

作者：

Ines Sifaoui

Eulalia Capote -Yanes

María Reyes-Batlle

Rubén L. Rodríguez-Expósito

Isabel L. Bazzocchi

Ignacio A. Jiménez

José E. Piñero

Jacob Lorenzo-Morales

Lindell K. Weaver

机构：

[1] Instituto Universitario De Enfermedades Tropicales Y Salud Pública De Canarias,Departamento de Obstetricia, Ginecología, Pediatría, Medicina Preventiva Y Salud Pública, Toxicología, Medicina Legal Y Forense Y Parasitología

[2] Universidad De La Laguna,Servicio de Oftalmología

[3] Universidad De La Laguna,Departamento de Química Orgánica

[4] Red de Investigación Cooperativa en Enfermedades Tropicales (RICET),Intermountain Medical Center

[5] Hospital Universitario Nuestra Señora de La Candelaria,undefined

[6] Instituto Universitario de Bio-Orgánica Antonio González,undefined

[7] Universidad de La Laguna,undefined

[8] Hyperbaric Medicine and Wound Care,undefined

[9] UT and LDS Hospital,undefined

[10] University of Utah School of Medicine,undefined

来源：

Parasitology Research | 2021年 / 120卷

关键词：

spp; Viability; Reactive oxygen species; Oxygen therapy;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Efficacious treatments against Acanthamoeba Keratitis (AK) is challenging, often ineffective and linked to the intragenotype variation in the drug efficacy. Increased oxygen can facilitate host response and can inhibit some organisms. Herein, we report the effect of increased oxygen concentrations on Acanthamoeba spp. growth and its effect on ROS (reactive oxygen species) production. The exposition to pure oxygen could reduce cell growth by at least 60% for Acanthamoeba castellanii Neff, Acanthamoeba polyphaga, and Acanthamoeba griffini. The increase in ROS production confirming that oxygen cell’s growth inhibition was due to oxidative stress. Further studies are needed to determine oxygen saturation level, time of oxygen exposition, and number of sessions needed to eliminate the parasite.

引用

页码：3001 / 3005

页数：4

共 50 条

[1] High oxygen concentrations inhibit Acanthamoeba spp.
Sifaoui, Ines
Yanes, Eulalia Capote
Reyes-Batlle, Maria
Rodriguez-Exposito, Ruben L.
Bazzocchi, Isabel L.
Jimenez, Ignacio A.
Pinero, Jose E.
Lorenzo-Morales, Jacob
Weaver, Lindell K.
[J]. PARASITOLOGY RESEARCH, 2021, 120 (08) : 3001 - 3005
[2] Acanthamoeba spp.
Liempi, Daniela
Saldivia, Ramon
Flores-Martin, Sandra N.
[J]. REVISTA CHILENA DE INFECTOLOGIA, 2024, 41 (01): : 165 - 166
[3] Quantification of Acanthamoeba spp. Motility
Campolo, Allison
Lara, Esther
Crary, Monica
[J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2024, (211):
[4] Immunopathogenicity of Acanthamoeba spp. in the Brain and Lungs
Kot, Karolina
Lanocha-Arendarczyk, Natalia
Kosik-Bogacka, Danuta
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (03) : 1 - 21
[5] Acanthamoeba spp. as agents of disease in humans
Marciano-Cabral, F
Cabral, G
[J]. CLINICAL MICROBIOLOGY REVIEWS, 2003, 16 (02) : 273 - +
[6] Acanthamoeba spp. as vehicle and reservoir of adenoviruses
Scheid, Patrick
Schwarzenberger, Rafael
[J]. PARASITOLOGY RESEARCH, 2012, 111 (01) : 479 - 485
[7] Diagnosis of Acanthamoeba spp. keratitis with PCR
Zamfir, O.
Yera, H.
Bourcier, T.
Batellier, L.
Dupouy-Camet, J.
Tourte-Schaeffer, C.
Chaumeil, C.
[J]. JOURNAL FRANCAIS D OPHTALMOLOGIE, 2006, 29 (09): : 1034 - 1040
[8] Acanthamoeba spp. as vehicle and reservoir of adenoviruses
Patrick Scheid
Rafael Schwarzenberger
[J]. Parasitology Research, 2012, 111 : 479 - 485
[9] Acanthamoeba spp. as opportunistic pathogens parasites
Castrillon, Juan C.
Orozco, Lina P.
[J]. REVISTA CHILENA DE INFECTOLOGIA, 2013, 30 (02): : 147 - 155
[10] Acanthamoeba spp. as vehicles of pathogenic bacteria
Hadas, E
Derda, M
Winiecka-Krusnell, J
Sulek-Piatkowska, A
[J]. ACTA PARASITOLOGICA, 2004, 49 (04) : 276 - 280

← 1 2 3 4 5 →