The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

被引：0
|
作者：
Eleni Georgiadou
Elizabeth Haythorne
Matthew T. Dickerson
Livia Lopez-Noriega
Timothy J. Pullen
Gabriela da Silva Xavier
Samuel P. X. Davis
Aida Martinez-Sanchez
Francesca Semplici
Rosario Rizzuto
James A. McGinty
Paul M. French
Matthew C. Cane
David A. Jacobson
Isabelle Leclerc
Guy A. Rutter
机构：
[1] Imperial College London,Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction
[2] Vanderbilt University,Department of Molecular Physiology and Biophysics
[3] Imperial College London,Photonics Group, Department of Physics
[4] University of Padova,Department of Biomedical Sciences
来源：
Diabetologia | 2020年 / 63卷
关键词：
Calcium; Glucose homeostasis; Insulin secretion; Mitochondria; Mitochondrial Ca; uniporter (MCU); Pancreatic beta cells; Type 2 diabetes;
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学科分类号：
摘要：
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页码：1368 / 1381
页数：13
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    Georgiadou, Eleni
    Haythorne, Elizabeth
    Dickerson, Matthew T.
    Lopez-Noriega, Livia
    Pullen, Timothy J.
    da Silva Xavier, Gabriela
    Davis, Samuel P. X.
    Martinez-Sanchez, Aida
    Semplici, Francesca
    Rizzuto, Rosario
    McGinty, James A.
    French, Paul M.
    Cane, Matthew C.
    Jacobson, David A.
    Leclerc, Isabelle
    Rutter, Guy A.
    [J]. DIABETOLOGIA, 2020, 63 (07) : 1368 - 1381
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