机构:Chinese Academy of Medical Sciences & Peking Union Medical College,Institute of Basic Medical Sciences & School of Basic Medicine, Center of Excellence in Tissue Engineering
Shihua Wang
Xuebin Qu
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机构:Chinese Academy of Medical Sciences & Peking Union Medical College,Institute of Basic Medical Sciences & School of Basic Medicine, Center of Excellence in Tissue Engineering
Xuebin Qu
Robert Chunhua Zhao
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机构:Chinese Academy of Medical Sciences & Peking Union Medical College,Institute of Basic Medical Sciences & School of Basic Medicine, Center of Excellence in Tissue Engineering
Robert Chunhua Zhao
机构:
[1] Chinese Academy of Medical Sciences & Peking Union Medical College,Institute of Basic Medical Sciences & School of Basic Medicine, Center of Excellence in Tissue Engineering
Mesenchymal stem cells (MSC) have generated a great amount of enthusiasm over the past decade as a novel therapeutic paradigm for a variety of diseases. Currently, MSC based clinical trials have been conducted for at least 12 kinds of pathological conditions, with many completed trials demonstrating the safety and efficacy. This review provides an overview of the recent clinical findings related to MSC therapeutic effects. Roles of MSCs in clinical trials conducted to treat graft-versus-host-disease (GVHD) and cardiovascular diseases are highlighted. Clinical application of MSC are mainly attributed to their important four biological properties- the ability to home to sites of inflammation following tissue injury when injected intravenously; to differentiate into various cell types; to secrete multiple bioactive molecules capable of stimulating recovery of injured cells and inhibiting inflammation and to perform immunomodulatory functions. Here, we will discuss these four properties. Moreover, the issues surrounding clinical grade MSCs and principles for MSC therapeutic approaches are also addressed on the transition of MSCs therapy from bench side to bedside.
机构:Chinese Acad Med Sci, Ctr Excellence Tissue Engn, Inst Basic Med Sci, Beijing 100005, Peoples R China
Wang, Shihua
Qu, Xuebin
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机构:Chinese Acad Med Sci, Ctr Excellence Tissue Engn, Inst Basic Med Sci, Beijing 100005, Peoples R China
Qu, Xuebin
Zhao, Robert Chunhua
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机构:
Chinese Acad Med Sci, Ctr Excellence Tissue Engn, Inst Basic Med Sci, Beijing 100005, Peoples R ChinaChinese Acad Med Sci, Ctr Excellence Tissue Engn, Inst Basic Med Sci, Beijing 100005, Peoples R China
机构:Laboratory of Immune Regulation, Convergent Research Consortium for Immunologic Disease, The Catholic University of Korea, College of Medicine, Seoul
Kim, Nayoun
Cho, Seok-Goo
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机构:Laboratory of Immune Regulation, Convergent Research Consortium for Immunologic Disease, The Catholic University of Korea, College of Medicine, Seoul
Cho, Seok-Goo
KOREAN JOURNAL OF INTERNAL MEDICINE,
2013,
28
(04):
: 387
-
402
机构:
Buddhist Tzu Chi Gen Hosp, Dept Pediat, 707 Chung Yang Rd,Sec 3, Hualien 970, Taiwan
Tzu Chi Univ, Inst Med Sci, Hualien, TaiwanBuddhist Tzu Chi Gen Hosp, Dept Pediat, 707 Chung Yang Rd,Sec 3, Hualien 970, Taiwan
Chang, Yu-Hsun
Liu, Hwan-Wun
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机构:
Tzu Chi Univ, Inst Med Sci, Hualien, Taiwan
Buddhist Tzu Chi Gen Hosp, Dept Occupat Med, 707 Chung Yang Rd,Sec 3, Hualien 970, TaiwanBuddhist Tzu Chi Gen Hosp, Dept Pediat, 707 Chung Yang Rd,Sec 3, Hualien 970, Taiwan
Liu, Hwan-Wun
Wu, Kun-Chi
论文数: 0引用数: 0
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机构:
Buddhist Tzu Chi Gen Hosp, Dept Orthoped, 707 Chung Yang Rd,Sec 3, Hualien 970, TaiwanBuddhist Tzu Chi Gen Hosp, Dept Pediat, 707 Chung Yang Rd,Sec 3, Hualien 970, Taiwan
机构:
Cent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R China
Zuo, Wanyun
Xie, Bingyu
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R China
Xie, Bingyu
Li, Chenglong
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机构:
Cent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R China
Li, Chenglong
Yan, Yuhan
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R China
Yan, Yuhan
Zhang, Yangyi
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机构:
Cent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R China
Zhang, Yangyi
Liu, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Inst Human Reprod & Stem Cell Engn, Xiangya Sch Med, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R China
Liu, Wei
Huang, Jufang
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Sch Med, Dept Anat & Neurobiol, Changsha 410013, Hunan, Peoples R ChinaCent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R China
Huang, Jufang
Chen, Dan
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Sch Med, Dept Anat & Neurobiol, Changsha 410013, Hunan, Peoples R ChinaCent South Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R China
机构:
Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Ctr Dino Ferrari,Lab Cellule Staminali, Dipartimento Fisiopatol Med Chirurg & Trapianti, I-20122 Milan, ItalyUniv Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Ctr Dino Ferrari,Lab Cellule Staminali, Dipartimento Fisiopatol Med Chirurg & Trapianti, I-20122 Milan, Italy
Farini, Andrea
论文数: 引用数:
h-index:
机构:
Sitzia, Clementina
Erratico, Silvia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Ctr Dino Ferrari,Lab Cellule Staminali, Dipartimento Fisiopatol Med Chirurg & Trapianti, I-20122 Milan, ItalyUniv Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Ctr Dino Ferrari,Lab Cellule Staminali, Dipartimento Fisiopatol Med Chirurg & Trapianti, I-20122 Milan, Italy
Erratico, Silvia
Meregalli, Mirella
论文数: 0引用数: 0
h-index: 0
机构:
Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Ctr Dino Ferrari,Lab Cellule Staminali, Dipartimento Fisiopatol Med Chirurg & Trapianti, I-20122 Milan, ItalyUniv Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Ctr Dino Ferrari,Lab Cellule Staminali, Dipartimento Fisiopatol Med Chirurg & Trapianti, I-20122 Milan, Italy
Meregalli, Mirella
Torrente, Yvan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Ctr Dino Ferrari,Lab Cellule Staminali, Dipartimento Fisiopatol Med Chirurg & Trapianti, I-20122 Milan, ItalyUniv Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Ctr Dino Ferrari,Lab Cellule Staminali, Dipartimento Fisiopatol Med Chirurg & Trapianti, I-20122 Milan, Italy
机构:
Univ Milan, Ist Nazl Tumori, Med Oncol Unit Cristina Gandini, I-20133 Milan, ItalyUniv Milan, Ist Nazl Tumori, Med Oncol Unit Cristina Gandini, I-20133 Milan, Italy
Carlo-Stella, C
Gianni, MA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Milan, Ist Nazl Tumori, Med Oncol Unit Cristina Gandini, I-20133 Milan, ItalyUniv Milan, Ist Nazl Tumori, Med Oncol Unit Cristina Gandini, I-20133 Milan, Italy