Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes

被引:0
|
作者
Tomas I. Gonzales
Kate Westgate
Tessa Strain
Stefanie Hollidge
Justin Jeon
Dirk L. Christensen
Jorgen Jensen
Nicholas J. Wareham
Søren Brage
机构
[1] University of Cambridge,MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science
[2] Yonsei University,Department Physical Performance
[3] University of Copenhagen,undefined
[4] Norwegian School of Sport Sciences,undefined
来源
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Cardiorespiratory fitness (CRF) is associated with mortality and cardiovascular disease, but assessing CRF in the population is challenging. Here we develop and validate a novel framework to estimate CRF (as maximal oxygen consumption, VO2max) from heart rate response to low-risk personalised exercise tests. We apply the method to examine associations between CRF and health outcomes in the UK Biobank study, one of the world’s largest and most inclusive studies of CRF, showing that risk of all-cause mortality is 8% lower (95%CI 5–11%, 2670 deaths among 79,981 participants) and cardiovascular mortality is 9% lower (95%CI 4–14%, 854 deaths) per 1-metabolic equivalent difference in CRF. Associations obtained with the novel validated CRF estimation method are stronger than those obtained using previous methodology, suggesting previous methods may have underestimated the importance of fitness for human health.
引用
收藏
相关论文
共 50 条
  • [1] Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose-response relationships with disease outcomes
    Gonzales, Tomas, I
    Westgate, Kate
    Strain, Tessa
    Hollidge, Stefanie
    Jeon, Justin
    Christensen, Dirk L.
    Jensen, Jorgen
    Wareham, Nicholas J.
    Brage, Soren
    [J]. SCIENTIFIC REPORTS, 2021, 11 (01)
  • [2] Author Correction: Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes
    Tomas I.Gonzales
    Kate Westgate
    Tessa Strain
    Stefanie Hollidge
    Justin Jeon
    Dirk L. Christensen
    Jorgen Jensen
    Nicholas J. Wareham
    Søren Brage
    [J]. Scientific Reports, 13
  • [3] Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose-response relationships with disease outcomes (vol 11, 15315, 2021)
    Gonzales, Tomas I.
    Westgate, Kate
    Strain, Tessa
    Hollidge, Stefanie
    Jeon, Justin
    Christensen, Dirk L.
    Jensen, Jorgen
    Wareham, Nicholas J.
    Brage, Soren
    [J]. SCIENTIFIC REPORTS, 2023, 13 (01)
  • [4] Cardiorespiratory Fitness, Workload, and the Blood Pressure Response to Exercise Testing
    Schultz, Martin G.
    La Gerche, Andre
    Sharman, James E.
    [J]. EXERCISE AND SPORT SCIENCES REVIEWS, 2022, 50 (01): : 25 - 30
  • [5] Cardiorespiratory fitness testing and cardiovascular disease risk in male steelworkers
    Gray, B. J.
    Stephens, J. W.
    Williams, S. P.
    Davies, C. A.
    Turner, D.
    Bracken, R. M.
    [J]. OCCUPATIONAL MEDICINE-OXFORD, 2017, 67 (01): : 38 - 43
  • [6] The Influence of Exercise Volume on Cardiorespiratory Fitness and Cardiovascular Disease Risk Factors
    Burke, Thomas
    Ostojic, Kelsie
    Koontz, Nicole
    Kaminsky, Leonard A.
    Harber, Matthew
    [J]. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2017, 49 (05): : 319 - 319
  • [7] Cardiorespiratory Response to Exercise Testing in Individuals With Alzheimer's Disease
    Billinger, Sandra A.
    Vidoni, Eric D.
    Honea, Robyn A.
    Burns, Jeffrey M.
    [J]. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2011, 92 (12): : 2000 - 2005
  • [8] Treatment outcomes and prognostic factors in children with hepatoblastoma using a risk-stratified approach
    Srinivasan, Shyam
    Prasad, Maya
    Parambil, Badira C. C.
    Shrimal, Anurag
    Gollamudi, Venkata Rama Mohan
    Subramani, Vignesh
    Ramadwar, Mukta
    Khanna, Nehal
    Baheti, Akshay D.
    Gala, Kunal
    Patil, Vasundhara
    Laskar, Siddhartha
    Qureshi, Sajid
    Chinnaswamy, Girish
    [J]. PEDIATRIC BLOOD & CANCER, 2023, 70 (07)
  • [9] Outcomes Assessment Based on a Risk-Stratified Simple Score After Orthotopic Heart Transplantation
    Morris, K. L.
    Lane, K. A.
    Lushin, E.
    Finet, J.
    Gradus-Pizlo, I.
    Hadi, A.
    Caccamo, M.
    [J]. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2017, 36 (04): : S301 - S301
  • [10] Cardiorespiratory Fitness and Reclassification of Risk for Incidence of Heart Failure The Veterans Exercise Testing Study
    Myers, Jonathan
    Kokkinos, Peter
    Chan, Khin
    Dandekar, Eshan
    Yilmaz, Bilge
    Nagare, Atul
    Faselis, Charles
    Soofi, Muhammad
    [J]. CIRCULATION-HEART FAILURE, 2017, 10 (06)