Phase II Study of Single Agent Paclitaxel in Adult Patients with Relapsed Acute Lymphocytic Leukemia

被引：0
|
作者：
Dawn E. Colburn
Deborah A. Thomas
Francis J. Giles
机构：
[1] The University of Texas,Department of Leukemia
[2] M.D. Anderson Cancer Center,undefined
来源：
Investigational New Drugs | 2003年 / 21卷
关键词：
paclitaxel; refractory; acute lymphocytic leukemia; adult;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: A phase II study of paclitaxel in patients with relapsed adult acute lymphocytic leukemia (ALL) was conducted. Methods: Patients with relapsed ALL, no more than one prior salvage regimen, and no overt hepatic, renal, or cardiac dysfunction were eligible. Patients received paclitaxel 250 mg/m2 given as a continuous 24 -h intravenous infusion repeated every 3–4 weeks. Results: Eight patients received 13 courses of paclitaxel. One transient partial response was observed. The only severe extramedullary toxicities observed were Grade 3 myalgias and arthralgias. Conclusion: The study paclitaxel regimen was ineffective in refractory adult ALL.
引用
收藏
页码：109 / 111
页数：2
相关论文
共 50 条
  • [1] Phase II study of single agent paclitaxel in adult patients with relapsed acute lymphocytic leukemia
    Colburn, DE
    Thomas, DA
    Giles, FJ
    INVESTIGATIONAL NEW DRUGS, 2003, 21 (01) : 109 - 111
  • [2] Results of paclitaxel (Taxol™) in adult patients with relapsed acute lymphocytic leukemia (ALL).
    Colburn, D
    O'Brien, S
    Thomas, D
    Beran, M
    Estey, E
    Giles, FJ
    BLOOD, 2001, 98 (11) : 210B - 210B
  • [3] Treatment of Relapsed Acute Lymphocytic Leukemia in Adult Patients
    Molina, John C.
    Carraway, Hetty E.
    CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2024, 25 (08) : 993 - 1010
  • [4] Phase II study of sphingosomal vincristine in patients with recurrent or refractory adult acute lymphocytic leukemia
    Thomas, DA
    Sarris, AH
    Cortes, J
    Fadel, S
    O'Brien, S
    Giles, FJ
    Garcia-Manero, G
    Rodriguez, MA
    Cabanillas, F
    Kantarjian, H
    CANCER, 2006, 106 (01) : 120 - 127
  • [5] Phase II Study of Dasatinib in Relapsed or Refractory Chronic Lymphocytic Leukemia
    Amrein, Philip C.
    Attar, Eyal C.
    Takvorian, Tak
    Hochberg, Ephraim P.
    Ballen, Karen K.
    Leahy, Kathleen M.
    Fisher, David C.
    LaCasce, Ann S.
    Jacobsen, Eric D.
    Armand, Philippe
    Hasserjian, Robert P.
    Werner, Lillian
    Neuberg, Donna
    Brown, Jennifer R.
    CLINICAL CANCER RESEARCH, 2011, 17 (09) : 2977 - 2986
  • [6] A Phase I Study Using Single Agent Birinapant in Patients with Relapsed Myelodysplastic Syndrome and Acute Myelogenous Leukemia
    Frey, Noelle V.
    Luger, Selina
    Mangan, James
    Zebrowski, Alexis
    Loren, Alison W.
    Minderman, Hans
    Baird, John
    Porter, David L.
    Hexner, Elizabeth O.
    Kumar, Anita J.
    Luskin, Marlise R.
    Perl, Alexander E.
    Carroll, Martin
    BLOOD, 2014, 124 (21)
  • [7] A phase II study of single-agent gemtuzumab ozogamicin in relapsed/refractory pediatric acute myeloid leukemia (AML).
    Zwaan, CM
    Reinhardt, D
    Zimmermann, M
    Creutzig, U
    Kaspers, GJL
    JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) : 806S - 806S
  • [8] A phase II study of bisantrene in patients with relapsed/refractory acute myeloid leukemia
    Canaani, Jonathan
    Danylesko, Ivetta
    Shemtov, Noga
    Zlotnick, Maya
    Lozinsky, Kira
    Benjamini, Ohad
    Yerushalmi, Ronit
    Nagar, Meital
    Dor, Chen
    Shimoni, Avichai
    Avigdor, Abraham
    Nagler, Arnon
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2021, 106 (02) : 260 - 266
  • [9] ACADESINE FOR PATIENTS WITH RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA: A MULTICENTRE PHASE I/II STUDY
    van den Neste, E.
    Janssens, A.
    Gonzalez-Barca, E.
    Cazin, B.
    Terol, M. J.
    Levy, V.
    Perez de Oteyza, J.
    Saunders, A.
    De Elias, M.
    Campas, C.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 : 325 - 325
  • [10] A Phase II Study of Bisantrene in Patients with Relapsed/Refractory Acute Myeloid Leukemia
    Canaani, Jonathan
    Danilesko, Ivetta
    Shem-Tov, Noga
    Zlotnick, Maya
    Lozinsky, Kira
    Benjamini, Ohad
    Yerushalmi, Ronit
    Nagar, Meital
    Dor, Chen
    Shimoni, Avichai
    Avigdor, Abraham
    Nagler, Arnon
    BLOOD, 2020, 136
12345