Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy?

被引：0
|
作者：
H Ueno
K Kiyosawa
N Kaniwa
机构：
[1] National Cancer Center Hospital,Hepatobiliary and Pancreatic Oncology Division
[2] Oncology Business Unit,Division of Medicinal Safety Science
[3] National Institute of Health Sciences,undefined
来源：
British Journal of Cancer | 2007年 / 97卷
关键词：
gemcitabine; pharmacogenomics; polymorphisms; gene expression; tailor-made therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Gemcitabine is a deoxycytidine analogue that has a broad spectrum of antitumour activity in many solid tumours including pancreatic cancer. We have recently carried out a pharmacogenomic study in cancer patients treated with gemcitabine, and found that one genetic polymorphism of an enzyme involved in gemcitabine metabolism can cause interindividual variations in the pharmacokinetics and toxicity of this agent. In this paper, we review recent genetic studies of gemcitabine, and discuss the possibility of individualised cancer chemotherapy based on a pharmacogenomic approach.
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页码：145 / 151
页数：6
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