Analysis of Nonlinear Hepatic Clearance of a Cyclopentapeptide, BQ-123, with the Multiple Indicator Dilution Method Using the Dispersion Model

被引：0

作者：

Akihiro Hisaka

Tatsuji Nakamura

Yuichi Sugiyama

机构：

[1] Banyu Pharmaceutical Co. Ltd.,Development Research Laboratories

[2] Tsukuba Research Laboratories,Faculty of Pharmaceutical Sciences

[3] Banyu Pharmaceutical Co. Ltd.,undefined

[4] University of Tokyo,undefined

来源：

Pharmaceutical Research | 1999年 / 16卷

关键词：

nonlinear pharmacokinetics; dispersion model; multiple indicator dilution method; BQ-123; hepatic transport; finite difference method;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose. To bridge in vitro, in situ and in vivo kinetic analyses of the hepatic clearance of a cyclopentapeptide, BQ-123, by using dispersion models that assume nonlinear pharmacokinetics.

引用

页码：103 / 109

页数：6

共 10 条

[1] Analysis of nonlinear hepatic clearance of a cyclopentapeptide, BQ-123, with the multiple indicator dilution method using the dispersion model
Hisaka, A
Nakamura, T
Sugiyama, Y
PHARMACEUTICAL RESEARCH, 1999, 16 (01) : 103 - 109
[2] Hepatic clearance models - Comparison of the dispersion and Goresky models in outflow profiles from multiple indicator dilution rat liver studies
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Schwab, AJ
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Pang, KS
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[3] KINETICS OF HEPATIC TRANSPORT OF 4-METHYLUMBELLIFERONE IN RATS - ANALYSIS BY MULTIPLE INDICATOR DILUTION METHOD
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SAWADA, Y
IGA, T
HANANO, M
MORITA, K
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[4] KINETICS OF HEPATIC TRANSPORT OF 4-METHYLUMBELLIFERONE IN RATS - ANALYSIS BY MULTIPLE INDICATOR DILUTION METHOD
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[5] Analysis of nonlinear and nonsteady state hepatic extraction with the dispersion model using the finite difference method
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[6] Analysis of Nonlinear and Nonsteady State Hepatic Extraction with the Dispersion Model Using the Finite Difference Method
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[7] COMPARATIVE HEPATIC TRANSPORT OF DESGLYCYLATED AND CYCLIC METABOLITES OF RILMAZAFONE IN RATS - ANALYSIS BY MULTIPLE INDICATOR DILUTION METHOD
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[8] EFFECT OF ALBUMIN ON HEPATIC-UPTAKE OF WARFARIN IN NORMAL AND ANALBUMINEMIC MUTANT RATS - ANALYSIS BY MULTIPLE INDICATOR DILUTION METHOD
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[9] Phenomenological Model of the Clavulanic Acid production, inhibitor of the nzymes β-lactamases using a method of multiple regression analysis nonlinear
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[10] A Modified Couple Stress-Based Model for the Nonlinear Vibrational Analysis of Nano-Disks Using Multiple Scales Method
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