Ancient DNA reveals evolutionary origins of autoimmune diseases

被引：0
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作者：
William Barrie
Evan K. Irving-Pease
Eske Willerslev
Astrid K. N. Iversen
Lars Fugger
机构：
[1] University of Cambridge,Department of Zoology
[2] University of Cambridge,Department of Genetics
[3] University of Copenhagen,Section for Molecular Ecology and Evolution, Globe Institute
[4] University of Copenhagen,Lundbeck Foundation GeoGenetics Centre, Globe Institute
[5] University of Bremen,MARUM Center for Marine Environmental Sciences and Faculty of Geosciences
[6] University of Oxford,MRC Human Immunology Unit, John Radcliffe Hospital
[7] University of Oxford,Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital
来源：
Nature Reviews Immunology | 2024年 / 24卷
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摘要：
Most autoimmune diseases are caused by the interplay between common genetic risk variants and environmental factors. New studies of ancient genomes suggest that many of these variants evolved under strong selection pressures, probably due to lifestyle-specific environmental pathogens, the consequences of which shape the distribution of present-day disease risk and point to novel therapeutic interventions.
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页码：85 / 86
页数：1
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