Role of Insulin-like Growth Factor-1 in the Regulation of Skeletal Growth

被引：0
|
作者：
Subburaman Mohan
Chandrasekhar Kesavan
机构：
[1] Musculoskeletal Disease Center,Department of Medicine, Biochemistry and Physiology
[2] Research Service (151),undefined
[3] Jerry L Pettis VA Medical Center,undefined
[4] Loma Linda University,undefined
来源：
Current Osteoporosis Reports | 2012年 / 10卷
关键词：
Growth hormone; Insulin-like growth factors; Insulin-like growth factor-binding protein; Bone; Osteoblast; Chondrocyte; Local; Systemic; Endocrine; Skeletal development; Osteoporosis;
D O I：
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中图分类号：
学科分类号：
摘要：
The importance of the insulin-like growth factor (IGF)-I axis in the regulation of bone size and bone mineral density, two important determinants of bone strength, has been well established from clinical studies involving patients with growth hormone deficiency and IGF-I gene disruption. Data from transgenic animal studies involving disruption and overexpression of components of the IGF-I axis also provide support for a key role for IGF-I in bone metabolism. IGF-I actions in bone are subject to regulation by systemic hormones, local growth factors, as well as mechanical stress. In this review we describe findings from various genetic mouse models that pertain to the role of endocrine and local sources of IGF-I in the regulation of skeletal growth.
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页码：178 / 186
页数：8
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