Prion-like transmission of protein aggregates in neurodegenerative diseases

被引：0

作者：

Patrik Brundin

Ronald Melki

Ron Kopito

机构：

[1] Patrik Brundin is at the Neuronal Survival Unit,Ron Kopito is at the Department of Biology

[2] Wallenberg Neuroscience Center,undefined

[3] Lund University,undefined

[4] BMC A10,undefined

[5] 221 84 Lund,undefined

[6] Sweden. patrik.brundin@med.lu.se,undefined

[7] Ronald Melki is at the Laboratoire d'Enzymologie et Biochimie Structurales,undefined

[8] Centre National de la Recherche Scientifique,undefined

[9] 91198 Gif–sur–Yvette,undefined

[10] France. melki@lebs.cnrs-gif.fr,undefined

[11] Stanford University,undefined

[12] Stanford,undefined

[13] California 94305–5020,undefined

[14] USA. kopito@stanford.edu,undefined

来源：

Nature Reviews Molecular Cell Biology | 2010年 / 11卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Neurodegenerative diseases are associated with the accumulation of intracellular or extracellular protein aggregates that form because of protein misfolding. These aggregates are capable of crossing cellular membranes and can thereby directly contribute to the propagation of neurodegenerative disease pathogenesis, which might spread in a 'prion-like' manner.

引用

页码：301 / 307

页数：6

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