Analysis of microRNA-target interactions across diverse cancer types

被引：0
|
作者：
Anders Jacobsen
Joachim Silber
Girish Harinath
Jason T Huse
Nikolaus Schultz
Chris Sander
机构：
[1] Computational Biology Center,Department of Pathology and Human Oncology and Pathogenesis Program
[2] Memorial Sloan-Kettering Cancer Center,undefined
[3] Memorial Sloan-Kettering Cancer Center,undefined
来源：
Nature Structural & Molecular Biology | 2013年 / 20卷
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摘要：
Analysis of data from The Cancer Genome Atlas generates a pan-cancer network of 143 recurrent miRNA-target relationships. The identified miRNAs were frequently regulated by genetic and epigenetic alterations in cancer. The work also reveals that some miRNAs might coordinately regulate cancer pathways, such as miR-29 regulation of TET1 and TDG mRNAs, encoding components from the active DNA demethylation pathway.
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页码：1325 / 1332
页数：7
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