Synthesis and Neuropsychotropic Activity of Indole-Containing Gamma-Aminobutyric Acid Derivatives

被引：0
|
作者：
V. M. Berestovitskaya
O. S. Vasil’eva
E. S. Ostroglyadov
S. M. Aleksandrova
I. N. Tyurenkov
O. V. Merkushenkova
V. V. Bagmetova
机构：
[1] Herzen State Pedagogical University of Russia,
[2] Pskov State University,undefined
[3] Volgograd State Medical University,undefined
来源：
Pharmaceutical Chemistry Journal | 2018年 / 52卷
关键词：
2-pyrrolidones; 4-aminobutyric acids; γ-aminobutyric acids; GABA; neuropsychotropic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of indole-containing γ-aminobutyric acids (GABA) were synthesized via alkaline hydrolysis of 4-(indol-3-yl)-2-pyrrolidones. Their structures were confirmed by IR, PMR, and 13C NMR spectroscopy. Studies of the pharmacological properties of 4-amino-3-indolylbutanoic acids (GABA derivatives) showed that they possessed neuropsychotropic activity, the spectrum of which depended on the acid molecular structure. Nootropic properties prevailed for 4-amino-3-(indol-3-yl)butanoic acid; anxiolytic activity, for 4-amino-3-(1-benzylindol-3-yl)butanoic acid.
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页码：392 / 396
页数：4
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