An Integrated Synthesis-Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery

被引：0

作者：

Jill E. Hochlowski

Philip A. Searle

Noah P. Tu

Jeffrey Y. Pan

Stephen G. Spanton

Stevan W. Djuric

机构：

[1] Abbott Laboratories,Structural Chemistry, Advanced Technology, Global Research and Development

[2] Abbott Laboratories,Medicinal Chemistry Technologies, Advanced Technology, Global Research and Development

[3] Abbott Laboratories,Automation Engineering, Advanced Technology, Global Research and Development

来源：

Journal of Flow Chemistry | 2011年 / 1卷

关键词：

flow synthesis; high-throughput organic synthesis; high-throughput purification; segmented flow; meso-flow;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We report herein a high-throughput integrated synthesis—purification platform termed SWIFT (synthesis with integrated-flow technology) and processes that accelerate the rate at which validated small-molecule organic compounds are generated. A segmented-flow synthesizer was integrated to a preparative HPLC-MS, where each reaction product was purified immediately upon reaction completion. Further, automated structure-validation processes accelerate the rate at which drug discovery candidates are available for biological screening.

引用

页码：56 / 61

页数：5

共 17 条

[1] An Integrated Synthesis-Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery
Hochlowski, Jill E.
Searle, Philip A.
Tu, Noah P.
Pan, Jeffrey Y.
Spanton, Stephen G.
Djuric, Stevan W.
JOURNAL OF FLOW CHEMISTRY, 2011, 1 (02) : 56 - 61
[2] Digital design of an integrated purification system for continuous pharmaceutical manufacturing
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