Preparation of Bioactive Mesoporous Calcium Phosphate Granules

被引：0
|
作者：
O. N. Musskaya
A. I. Kulak
V. K. Krut’ko
Yu. A. Lesnikovich
V. V. Kazbanov
N. S. Zhitkova
机构：
[1] Belarusian Academy of Sciences,Institute of General and Inorganic Chemistry
[2] Belarussian State University,undefined
[3] Republican Scientific and Practical Centre for Pediatric Surgery,undefined
来源：
Inorganic Materials | 2018年 / 54卷
关键词：
calcium phosphates; hydroxyapatite; tricalcium phosphate; specific surface area; bioactivity;
D O I：
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中图分类号：
学科分类号：
摘要：
Mesoporous calcium phosphate granules ranging in mesopore size from 11 to 19 nm have been prepared using cryogenic processing (–18°C) of gels and extrusion of calcium phosphate paste. The granules based on acid calcium phosphates have a relatively small specific surface area (45 m2/g) in comparison with the neutral and basic calcium phosphates (84–155 m2/g). Preclinical in vivo trials on rats show that the presence of calcium phosphate granules in a bone defect considerably accelerates reparative osteogenesis in comparison with a control group of animals.
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页码：117 / 124
页数：7
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