Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model

被引：0
|
作者：
Ketil A. Camilio
Meng-Yu Wang
Brynjar Mauseth
Stein Waagene
Gunnar Kvalheim
Øystein Rekdal
Baldur Sveinbjørnsson
Gunhild M. Mælandsmo
机构：
[1] Institute for Cancer Research,Department of Tumor Biology
[2] Oslo University Hospital,Department of Cellular Therapy
[3] Oslo University Hospital,Department of Medical Biology
[4] Lytix Biopharma AS,Division of Cancer, Surgery and Transplantation
[5] The Arctic University of Norway,Institute of Clinical Medicine
[6] Oslo University Hospital,undefined
[7] University of Oslo,undefined
[8] Oslo Cancer Cluster Incubator,undefined
来源：
Breast Cancer Research | / 21卷
关键词：
Triple-negative breast cancer; Immunochemotherapy; Combination therapy; Immunotherapy; Oncolytic peptide; LTX-315; Doxorubicin; DAMPs; ICD;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model
    Camilio, Ketil A.
    Wang, Meng-Yu
    Mauseth, Brynjar
    Waagene, Stein
    Kvalheim, Gunnar
    Rekdal, Oystein
    Sveinbjornsson, Baldur
    Maelandsmo, Gunhild M.
    BREAST CANCER RESEARCH, 2019, 21 (1)
  • [2] Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide
    Haug, Bengt Erik
    Camilio, Ketil Andre
    Eliassen, Liv Tone
    Stensen, Wenche
    Svendsen, John Sigurd
    Berg, Kristel
    Mortensen, Bjarte
    Serin, Guillaume
    Mirjolet, Jean-Francois
    Bichat, Francis
    Rekdal, Oystein
    JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (07) : 2918 - 2927
  • [3] Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model
    Nestvold, Janne
    Wang, Meng-Yu
    Camilio, Ketil A.
    Zinocker, Severin
    Tjelle, Torunn Elisabeth
    Lindberg, Alf
    Haug, Bengt Erik
    Kvalheim, Gunnar
    Sveinbjornsson, Baldur
    Rekdal, Oystein
    ONCOIMMUNOLOGY, 2017, 6 (08):
  • [4] Doxorubicin Conjugation to Reovirus Improves Oncolytic Efficacy in Triple-Negative Breast Cancer
    Berry, Jameson T. L.
    Munoz, Luis E.
    Stewart, Roxana M. Rodriguez
    Selvaraj, Periasamy
    Mainou, Bernardo A.
    MOLECULAR THERAPY-ONCOLYTICS, 2020, 18 : 556 - 572
  • [5] Potential therapeutic target for triple-negative breast cancer
    Gilbert, Judith A.
    LANCET ONCOLOGY, 2012, 13 (08): : E330 - E330
  • [6] The oncolytic peptide LTX-315 enhances tumor-specific immune responses and tumor regression in murine 4T1 breast cancer when combined with doxorubicin
    Wang, Meng Yu
    Kristian, Alexander
    Camilio, Ketil
    Sveinbjornsson, Baldur
    Maelandsmo, Gunhild Mari
    Kvalheim, Gunnar
    Rekdal, Oystein
    CANCER RESEARCH, 2016, 76
  • [7] The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization
    Zhou, Heng
    Forveille, Sabrina
    Sauvat, Allan
    Sica, Valentina
    Izzo, Valentina
    Durand, Sylvere
    Mueller, Kevin
    Liu, Peng
    Zitvogel, Laurence
    Rekdal, Oystein
    Kepp, Oliver
    Kroemer, Guido
    ONCOTARGET, 2015, 6 (29) : 26599 - 26614
  • [8] Ferroptosis and triple-negative breast cancer: Potential therapeutic targets
    Xu, Na
    Li, Baohong
    Liu, Yong
    Yang, Cui
    Tang, Siqi
    Cho, William C.
    Huang, Zunnan
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [9] Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer
    Li, Chia-Jung
    Tzeng, Yen-Dun Tony
    Chiu, Yi-Han
    Lin, Hung-Yu
    Hou, Ming-Feng
    Chu, Pei-Yi
    CANCERS, 2021, 13 (12)
  • [10] Cordycepin Enhances the Therapeutic Efficacy of Doxorubicin in Treating Triple-Negative Breast Cancer
    Huang, Haichen
    Li, Xiaomin
    Wu, Wenya
    Liu, Chengyi
    Shao, Yunhe
    Wu, Xiaoping
    Fu, Junsheng
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (13)
12345