15-Deoxy-Δ12,14-prostaglandin J2inhibits IL-1β-induced cyclooxygenase-2 expression in human synovial fibroblasts through a histone deacetylase-independent mechanism

被引：0
|
作者：
K Farrajota
H Afif
J Martel-Pelletier
J-P Pelletier
X Li
S Cheng
M Lavigne
H Fahmi
机构：
[1] Hôpital Notre-Dame,Osteoarthritis Research Unit, Centre hospitalier de l'Université de Montréal
[2] Hôpital Maisonneuve-Rosemont,undefined
来源：
Arthritis Res Ther | / 6卷 / Suppl 3期
关键词：
GW9662; Chromatin Immunoprecipitation Assay; Gene Promoter Activation; Transient Transfection Experiment; Histone Acetylase;
D O I：
10.1186/ar1402
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] 15-deoxy-Δ 12,14-prostaglandin J2 inhibits il-1β-induced cyclooxygenase-2 expression in human synovial fibroblasts through a histone deacetylase-independent mechanism
    Farrajota, K
    Li, X
    Afif, H
    Martel-Pelletier, J
    Pelletier, JP
    Fahmi, H
    OSTEOARTHRITIS AND CARTILAGE, 2004, 12 : S76 - S76
  • [2] Inhibition of interleukin-1β-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Δ12,14-prostaglandin J2 through a histone deacetylase-independent mechanism
    Farrajota, K
    Cheng, S
    Martel-Pelletier, J
    Afif, H
    Pelletier, JP
    Li, XF
    Ranger, P
    Fahmi, H
    ARTHRITIS AND RHEUMATISM, 2005, 52 (01): : 94 - 104
  • [3] 15-Deoxy-Δ12,14-prostaglandin J2 inhibits IL-1β-induced cyclooxygenase-2 expression in mesangial cells
    Sawano, H
    Haneda, M
    Sugimoto, T
    Inoki, K
    Koya, D
    Kikkawa, R
    KIDNEY INTERNATIONAL, 2002, 61 (06) : 1957 - 1967
  • [4] 15d-PGJ2 inhibits IL-1b-induced cyclooxygenase-2 expression in human synovial fibroblasts through a histone deacetylase-independent mechanism
    Farrajota, K
    Cheng, S
    Afif, H
    Martel-Pelletier, J
    Pelletier, JP
    Li, XF
    Fahmi, H
    FASEB JOURNAL, 2005, 19 (04): : A286 - A286
  • [5] Effects of 15-deoxy-Δ12,14-prostaglandin J2 on the cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharide
    Inoue, K
    Takano, H
    Yanagisawa, R
    Morita, M
    Ichinose, T
    Sadakane, K
    Yoshino, S
    Yamaki, K
    Kumagai, Y
    Uchiyama, K
    Yoshikawa, T
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2004, 54 (11): : 711 - 714
  • [6] Histone Deacetylase Inhibitors and 15-Deoxy-Δ12,14-Prostaglandin J2 Synergistically Induce Apoptosis
    Koyama, Makoto
    Izutani, Yasuyuki
    Goda, Ahmed E.
    Matsui, Taka-aki
    Horinaka, Mano
    Tomosugi, Mitsuhiro
    Fujiwara, Jun
    Nakamura, Yoshitaka
    Wakada, Miki
    Yogosawa, Shingo
    Sowa, Yoshihiro
    Sakai, Toshiyuki
    CLINICAL CANCER RESEARCH, 2010, 16 (08) : 2320 - 2332
  • [7] Selective inhibition of cyclooxygenase-2 expression by 15-deoxy-Δ12,14-prostaglandin J2 in activated human astrocytes, but not in human brain macrophages
    Janabi, N
    JOURNAL OF IMMUNOLOGY, 2002, 168 (09): : 4747 - 4755
  • [8] 15-Deoxy-Δ12,14-prostaglandin J2 inhibits the expression of fractalkine in endothelial cells
    Imaizumi, T
    Yoshida, H
    Satoh, K
    ATHEROSCLEROSIS SUPPLEMENTS, 2003, 4 (02) : 310 - 310
  • [9] 15-Deoxy-Δ12,14-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-γ-independent mechanism
    Hinz, B
    Brune, K
    Pahl, A
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 302 (02) : 415 - 420
  • [10] 15-deoxy-Δ12,14-prostaglandin J2 inhibits IL-1β-induced IKK enzymatic activity and IκBα degradation in rat chondrocytes through a PPARγ-independent pathway
    Boyault, S
    Bianchi, A
    Moulin, D
    Morin, S
    Francois, M
    Netter, P
    Terlain, B
    Bordji, K
    FEBS LETTERS, 2004, 572 (1-3): : 33 - 40
12345