Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

被引：0

作者：

Nadine Honke

Namir Shaabani

Giuseppe Cadeddu

Ursula R Sorg

Dong-Er Zhang

Mirko Trilling

Karin Klingel

Martina Sauter

Reinhard Kandolf

Nicole Gailus

Nico van Rooijen

Christoph Burkart

Stephan E Baldus

Melanie Grusdat

Max Löhning

Hartmut Hengel

Klaus Pfeffer

Masato Tanaka

Dieter Häussinger

Mike Recher

Philipp A Lang

Karl S Lang

机构：

[1] Hepatology and Infectious Diseases,Department of Gastroenterology

[2] Heinrich-Heine-University,Department of Pathology, Division of Biological Sciences and Moores University of California San Diego Cancer Center

[3] Institute for Pathology,Department of Molecular Pathology

[4] Heinrich-Heine-University,Department of Molecular Cell Biology

[5] Institute of Medical Microbiology and Hospital Hygiene,Department of Rheumatology and Clinical Immunology

[6] Heinrich-Heine-University,Division of Immunology

[7] University of California San Diego,undefined

[8] Institute for Virology,undefined

[9] Heinrich-Heine-University,undefined

[10] Eberhard Karls University Tübingen,undefined

[11] Faculty of Medicine,undefined

[12] Vrije Universiteit,undefined

[13] Charité-University Medicine Berlin and German Rheumatism Research Center,undefined

[14] Laboratory for Innate Cellular Immunity,undefined

[15] RIKEN Research Center for Allergy and Immunology,undefined

[16] Children's Hospital,undefined

[17] Harvard Medical School,undefined

[18] Campbell Family Institute for Breast Cancer Research,undefined

[19] Ontario Cancer Institute,undefined

[20] University Health Network,undefined

[21] Institute for Immunology,undefined

[22] University of Essen,undefined

来源：

Nature Immunology | 2012年 / 13卷

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摘要：

Type 1 interferon limits virus replication. Lang and colleagues show that expression of Usp18 in metallophilic macrophages results in less interferon responsiveness, which allows locally restricted virus replication and the induction of adaptive immune responses.

引用

页码：51 / 57

页数：6

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