Oleic acid protects insulin-secreting INS-1E cells against palmitic acid-induced lipotoxicity along with an amelioration of ER stress

被引：0
|
作者：
Xiaohong Liu
Xin Zeng
Xuanming Chen
Ruixi Luo
Linzhao Li
Chengshi Wang
Jingping Liu
Jingqiu Cheng
Yanrong Lu
Younan Chen
机构：
[1] Sichuan University,Key Laboratory of Transplant Engineering and Immunology, NHFPC; Regenerative Medicine Research Center, Endocrinology Department, West China Hospital
来源：
Endocrine | 2019年 / 64卷
关键词：
Palmitic acid; Oleic acid; Apoptosis; ER stress; Pancreatic β cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：512 / 524
页数：12
相关论文
共 50 条
  • [1] Oleic acid protects insulin-secreting INS-1E cells against palmitic acid-induced lipotoxicity along with an amelioration of ER stress
    Liu, Xiaohong
    Zeng, Xin
    Chen, Xuanming
    Luo, Ruixi
    Li, Linzhao
    Wang, Chengshi
    Liu, Jingping
    Cheng, Jingqiu
    Lu, Yanrong
    Chen, Younan
    ENDOCRINE, 2019, 64 (03) : 512 - 524
  • [2] Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis
    Xin Zeng
    Min Zhu
    Xiaohong Liu
    Xuanmin Chen
    Yujia Yuan
    Lan Li
    Jingping Liu
    Yanrong Lu
    Jingqiu Cheng
    Younan Chen
    Nutrition & Metabolism, 17
  • [3] Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection
    Pardo, Virginia
    Gonzalez-Rodriguez, Agueda
    Muntane, Jordi
    Kozma, Sara C.
    Valverde, Angela M.
    FOOD AND CHEMICAL TOXICOLOGY, 2015, 80 : 298 - 309
  • [4] PPARδ is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction
    Ravnskjaer, Kim
    Frigerio, Francesca
    Boergesen, Michael
    Nielsen, Tina
    Maechler, Pierre
    Mandrup, Susanne
    JOURNAL OF LIPID RESEARCH, 2010, 51 (06) : 1370 - 1379
  • [5] Insulin-secreting INS-1E cells express functional TRPV1 channels
    Fagelskiold, Amanda Jabin
    Kannisto, Kristina
    Bostrom, Anna
    Hadrovic, Banina
    Farre, Cecilia
    Eweida, Mohamed
    Wester, Kenneth
    Islam, Md. Shahidul
    ISLETS, 2012, 4 (01)
  • [6] Peroxiredoxin 4 Improves Insulin Biosynthesis and Glucose-induced Insulin Secretion in Insulin-secreting INS-1E Cells
    Mehmeti, Ilir
    Lortz, Stephan
    Elsner, Matthias
    Lenzen, Sigurd
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (39) : 26904 - 26913
  • [7] Effect of substrate rigidity in tissue culture on the function of insulin-secreting INS-1E cells
    Naujok, O.
    Bandou, Y.
    Shikama, Y.
    Funaki, M.
    Lenzen, S.
    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2017, 11 (01) : 58 - 65
  • [8] PPARalpha plays a role in glucose stimulated insulin secretion and protects against lipotoxicity in INS-1E beta cells
    Frigerio, F.
    Bartley, C.
    Mandrup, S.
    Maechler, P.
    DIABETOLOGIA, 2006, 49 : 261 - 262
  • [9] Silencing the FABP3 gene in insulin-secreting cells reduces fatty acid uptake and protects against lipotoxicity
    Hyder, Ayman
    Sheta, Basma
    Eissa, Manar
    Schrezenmeir, Juergen
    ACTA DIABETOLOGICA, 2024, 61 (12) : 1577 - 1588
  • [10] DDX17 protects hepatocytes against oleic acid/palmitic acid-induced lipid accumulation
    Zhang, Xiaoyi
    An, Tong
    Zhang, Xiyue
    Shen, Tao
    Li, Hongxia
    Dou, Lin
    Huang, Xiuqing
    Man, Yong
    Tang, Weiqing
    Li, Jian
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 612 : 169 - 175
12345