Uptake and Efflux of Quinacrine, a Candidate for the Treatment of Prion Diseases, at the Blood-Brain Barrier

被引：0
|
作者：
Shinya Dohgu
Atsushi Yamauchi
Fuyuko Takata
Yasufumi Sawada
Shun Higuchi
Mikihiko Naito
Takashi Tsuruo
Susumu Shirabe
Masami Niwa
Shigeru Katamine
Yasufumi Kataoka
机构：
[1] Kyushu University,Department of Medico
[2] Fukuoka University,Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences
[3] University of Tokyo,Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences
[4] Nagasaki University Graduate School of Biomedical Sciences,Institute of Molecular and Cellular Biosciences
来源：
Cellular and Molecular Neurobiology | 2004年 / 24卷
关键词：
quinacrine; blood–brain barrier; mouse brain endothelial cells; P-glyco-protein; organic cation transporter; Creutzfeldt–Jakob disease;
D O I：
暂无
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学科分类号：
摘要：
1. A clinical trial of quinacrine in patients with Creutzfeldt–Jakob disease is now in progress. The permeability of drugs through the blood–brain barrier (BBB) is a determinant of their therapeutic efficacy for prion diseases. The mechanism of quinacrine transport across the BBB was investigated using mouse brain endothelial cells (MBEC4).
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页码：205 / 217
页数：12
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