Immunomodulation of autoimmune and inflammatory diseases with intravenous immunoglobulin

被引：0
|
作者：
A. Ephrem
N. Misra
G. Hassan
S. Dasgupta
S. Delignat
J.-P. Duong Van Huyen
S. Chamat
F. Prost
S. Lacroix-Desmazes
S. V. Kavery
M. D Kazatchkine
机构：
[1] INSERM U430 and Université Pierre et Marie Curie (UPMC-Paris 6),
[2] Hôpital Broussais,undefined
来源：
Clinical and Experimental Medicine | 2005年 / 5卷
关键词：
Intravenous immunoglobulin; Autoimmune disorders; Inflammatory diseases; Mechanisms;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Intravenous immunoglobulin (IVIg) has been used in the treatment of primary and secondary antibody deficiencies for over two decades. Since the early 1980s, the therapeutic efficacy of IVIg has been established in idiopathic thrombocytopenic purpura, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, dermatomyositis and Kawasaki syndrome, and the prevention of graft versus host disease in recipients of allogeneic bone marrow transplants. Its use has also been reported in a large number of other autoimmune and systemic inflammatory conditions. In this review, we discuss the mechanisms by which IVIg exerts immunomodulatory effects in immune pathologies.
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页码：135 / 140
页数：5
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