Reactions of 4,5-dihydro-5-methyl-3H-spiro[benz-2-azepine-3-cyclohexane] N-oxide with some nucleophilic reagents

被引：0
|
作者：
Varlamov A.V. [1 ]
Grudinin D.G. [1 ]
Chernyshev A.I. [1 ]
Levov A.N. [1 ]
Golovtsov N.I. [1 ]
Borisov R.S. [1 ]
机构：
[1] Russian People's Friendship University
来源：
Chemistry of Heterocyclic Compounds | 2001年 / 37卷 / 03期
关键词：
Benz-2-azepines; Cyclic hydroxylamines; Cyclic nitrones; Nucleophilic additions; Oxidation;
D O I：
10.1023/A:1017515318197
中图分类号：
学科分类号：
摘要：
4,5-Dihydro-5-methyl-3H-spiro[benz-2-azepine-3-cyclohexane] N-oxide reacted with cyanide ion and isopropyl magnesium bromide to give the corresponding 1-cyano- and 1-isopropyl-4,5-dihydro-5-methyl- 3H-spiro[benz-2-azepine-3-cyclohexane], but reaction with phenyl magnesium bromide, benzyl magnesium chloride, and nitromethane gave cyclic hydroxylamines: 1-substituted N-hydroxy-1,2,4,5-tetrahydro-5- methyl-3H-spiro[benz-2-azepine-3-cyclohexanes] which were oxidized to the corresponding nitrones.
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页码：346 / 352
页数：6
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