Synthesis and Properties of Ethyl Esters of 4-Dialkylamino-2-methylthiothieno[2,3-d]pyrimidine-6-carboxylic Acids

被引：0

作者：

S. Tumkevicius

A. Kaminskas

机构：

[1] Vilnius University,Faculty of Organic Chemistry

来源：

Chemistry of Heterocyclic Compounds | 2003年 / 39卷 / 5期

关键词：

pyrimidines; thieno[2,3-; ]pyrimidines; reduction; cyclocondensation;

D O I：

10.1023/A:1025114703659

中图分类号：

学科分类号：

摘要：

The reaction of 4-dialkylamino-6-chloro-2-methylthiopyrimidine-5-carbaldehydes with ethyl mercaptoacetate in the presence of triethylamine gives the corresponding ethyl esters of thieno[2,3-d]pyrimidine-6-carboxylic acids. These esters were subjected to alkaline hydrolysis, hydrazinolysis, and lithium aluminum hydride reduction to give the corresponding acids, hydrazides, and (thieno[2,3-d]pyrimidin-6-yl)methanols.

引用

页码：664 / 668

页数：4

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