Synthesis and Antiradical and Hemorheological Activity of Compounds Based on 2,6-Diisobornyl-4-Methylphenol and Polysaccharides

被引：0
|
作者：
M. B. Plotnikov
O. I. Aliev
A. V. Sidekhmenova
E. V. Popova
O. I. Ostrikova
A. V. Kuchin
I. Yu. Chukicheva
M. A. Torlopov
机构：
[1] Russian Academy of Medical Sciences,E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch
[2] Russian Academy of Sciences,Institute of Chemistry, Komi Scientific Center, Ural Branch
来源：
Pharmaceutical Chemistry Journal | 2018年 / 51卷
关键词：
dibornol; inulin; carboxymethylcellulose; starch;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Antiradical and hemorheological activities of conjugates synthesized from 2,6-diisobornyl-4-methylphenol (dibornol) and polysaccharides [inulin, carboxymethylcellulose, hydroxyethyl starch (HES)] were studied in vitro. The dibornol—HES polymer conjugate exhibited the greatest antiradical activity of the tested compounds for the water-soluble stable radical ABTS•+ and limited statistically significantly the blood viscosity increase in an in vitro blood hyperviscosity model at a final concentration of 10–5 g/ml of blood.
引用
收藏
页码：863 / 866
页数：3
相关论文
共 50 条
  • [1] Synthesis and Antiradical and Hemorheological Activity of Compounds Based on 2,6-Diisobornyl-4-Methylphenol and Polysaccharides
    Plotnikov, M. B.
    Aliev, O. I.
    Sidekhmenova, A. V.
    Popova, E. V.
    Ostrikova, O. I.
    Kuchin, A. V.
    Chukicheva, I. Yu.
    Torlopov, M. A.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2018, 51 (10) : 863 - 866
  • [2] Synthesis of new 2,6-diisobornyl-4-methylphenol derivatives
    E. V. Buravlev
    I. Yu. Chukicheva
    I. A. Dvornikova
    A. V. Churakov
    . V. Kutchin
    Russian Journal of Organic Chemistry, 2012, 48 : 938 - 942
  • [3] Macromolecular antioxidants based on polysaccharides and 2,6-diisobornyl-4-methylphenol derivatives
    Vlasov, P. S.
    Sergeeva, O. Yu.
    Domnina, N. S.
    Chukicheva, I. Yu.
    Buravlev, E. V.
    Kuchin, A. V.
    CHEMISTRY OF NATURAL COMPOUNDS, 2012, 48 (04) : 531 - 534
  • [4] Macromolecular antioxidants based on polysaccharides and 2,6-diisobornyl-4-methylphenol derivatives
    P. S. Vlasov
    O. Yu. Sergeeva
    N. S. Domnina
    I. Yu. Chukicheva
    E. V. Buravlev
    A. V. Kuchin
    Chemistry of Natural Compounds, 2012, 48 : 531 - 534
  • [5] Synthesis of new 2,6-diisobornyl-4-methylphenol derivatives
    Buravlev, E. V.
    Chukicheva, I. Yu.
    Dvornikova, I. A.
    Churakov, A. V.
    Kutchin, A. V.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 48 (07) : 938 - 942
  • [6] Membrane protective properties of carboxy derivatives based on 2,6-diisobornyl-4-methylphenol
    E. V. Buravlev
    I. Yu. Chukicheva
    O. V. Sukrusheva
    O. G. Shevchenko
    A. V. Kutchin
    Russian Chemical Bulletin, 2015, 64 : 1406 - 1412
  • [7] SYNTHESIS OF INULIN AND STARCH DERIVATIVES WITH A 2,6-DIISOBORNYL-4-METHYLPHENOL (DIBORNOL™) FRAGMENT
    Torlopov, M. A.
    Chukicheva, I. Yu.
    Kuchin, A. V.
    CHEMISTRY OF NATURAL COMPOUNDS, 2012, 47 (06) : 867 - 869
  • [8] Membrane protective properties of carboxy derivatives based on 2,6-diisobornyl-4-methylphenol
    Buravlev, E. V.
    Chukicheva, I. Yu.
    Sukrusheva, O. V.
    Shevchenko, O. G.
    Kutchin, A. V.
    RUSSIAN CHEMICAL BULLETIN, 2015, 64 (06) : 1406 - 1412
  • [9] Synthesis of inulin and starch derivatives with a 2,6-diisobornyl-4-methylphenol (dibornolTM) fragment
    M. A. Torlopov
    I. Yu. Chukicheva
    A. V. Kuchin
    Chemistry of Natural Compounds, 2012, 47 : 867 - 869
  • [10] Cardioprotective Activity of 2,6-Diisobornyl-4-Methylphenol in Acute Myocardial Ischemia/Reperfusion in Rats
    Plotnikova, T. M.
    Chernysheva, G. A.
    Smol'yakova, V. A.
    Shchetinin, P. P.
    Kuchin, A. V.
    Chukicheva, I. Yu.
    Plotnikov, M. B.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2018, 165 (05) : 657 - 659
12345