High-affinity integration of hydroxyapatite nanoparticles with chemically modified silk fibroin

被引:0
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作者
Li Wang
Chunzhong Li
Mamoru Senna
机构
[1] East China University of Science & Technology,Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering
[2] Keio University,Department of Applied Chemistry, Faculty of Science and Technology
来源
关键词
hydroxyapatite; silk fibroin; chemical modification; microstructure; interfacial adhesion; nanocomposites; nanomedicine; bone;
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学科分类号
摘要
Hydroxyapatite (HA)-based nanocomposites were prepared by a co-precipitation method with silk fibroin (SF) serving as organic matrix. Silk fibroin was chemically modified with an alkali solution or an enzyme attempting to improve the interface between the mineral and the organic matrix. The influences of the alkali and enzyme pretreatments on microstructure and physicochemical properties of HA–SF composite were examined and compared. The results reveal that both the two kinds of pretreatments facilitate the formation of highly ordered three-dimensional porous network throughout the composites, increase the microhardness of the composite, and promote the preferential growth of HA crystallites along c-axis. Among all the as-prepared samples, the composite containing the enzyme pretreated SF shows desirable hierarchical microstructure with higher degree of organization and more uniform pore size distribution. Due to the enzyme pretreatment, HA crystallites undergo obvious changes in morphology from rod-like to␣whisker-like and in crystal growth towards more apparent epitaxy along c-axis. The alkali pretreatment induces the stronger chemical interactions between HA and SF and thus to strengthen the inorganic–organic interfacial adhesion. The newly developed HA–SF composites are expected to be attractive biomedical materials for bone repair and remodeling.
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页码:919 / 929
页数:10
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