Conserved structural elements in the V3 crown of HIV-1 gp120

被引：0
|
作者：
Xunqing Jiang
Valicia Burke
Maxim Totrov
Constance Williams
Timothy Cardozo
Miroslaw K Gorny
Susan Zolla-Pazner
Xiang-Peng Kong
机构：
[1] New York University School of Medicine,Department of Biochemistry
[2] Molsoft LLC,Department of Pathology
[3] New York University School of Medicine,Department of Pharmacology
[4] New York University School of Medicine,undefined
[5] Veterans Affairs New York Harbor Healthcare System,undefined
来源：
Nature Structural & Molecular Biology | 2010年 / 17卷
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摘要：
The V3 crown region of HIV-1 gp120 is involved in binding to co-receptors CCR5 and CXCR4, and show high sequence variability. Structural work with cross-clade neutralizing antibodies in complex with V3 peptides now reveals conserved structural elements in this variable region, which are minimally affected by sequence variation.
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页码：955 / 961
页数：6
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