Pathogenesis of HIV in the central nervous system

被引：142

作者：

Valcour V.

Sithinamsuwan P. ^{[1
]}

Letendre S. ^{[2
]}

Ances B. ^{[3
]}

机构：

[1] Division of Neurology, Department of Medicine, Phramongkutkloa Hospital, Thung Phyathai, Ratchthewi, Bangkok 10400

[2] HIV Neurobehavioral Research Center, University of California - San Diego, San Diego, CA 92103

[3] Department of Neurology, Washington University, Saint Louis, MO 63110, Box 8111

来源：

Current HIV/AIDS Reports | 2011年 / 8卷 / 1期

关键词：

Aging; AIDS dementia complex; Cerebrospinal fluid; Review;

D O I：

10.1007/s11904-010-0070-4

中图分类号：

学科分类号：

摘要：

HIV can infect the brain and impair central nervous system (CNS) function. Combination antiretroviral therapy (cART) has not eradicated CNS complications. HIV-associated neurocognitive disorders (HAND) remain common despite cART, although attenuated in severity. This may result from a combination of factors including inadequate treatment of HIV reservoirs such as circulating monocytes and glia, decreased effectiveness of cART in CNS, concurrent illnesses, stimulant use, and factors associated with prescribed drugs, including antiretrovirals. This review highlights recent investigations of HIV-related CNS injury with emphasis on cART-era neuropathological mechanisms in the context of both US and international settings. © 2010 The Author(s).

引用

页码：54 / 61

页数：7

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