Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017

被引：0
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作者：
Alexander Nagy
Ádám Dán
Lenka Černíková
Eliška Vitásková
Vlastimil Křivda
Jitka Horníčková
Roman Masopust
Kamil Sedlák
机构：
[1] State Veterinary Institute Prague,
[2] National Food Chain Safety Office,undefined
[3] Veterinary Diagnostic Institute,undefined
来源：
Archives of Virology | 2018年 / 163卷
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摘要：
Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided.
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页码：2219 / 2224
页数：5
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