1,25-dihydroxyvitamin D3 inhibits parathyroid hormone-related peptide mRNA expression in fetal rat long bones in culture

被引：0
|
作者：
Karmali R. [1 ]
Wolf N.N.-D.
Beyer I.
Hendy G.N. [2 ]
Bergmann P.
机构：
[1] Department of Medicine, 1020 Brussels, 4, Place van Gehuchten
[2] Calcium Research Laboratory, McGill University, Montreal
来源：
In Vitro Cellular & Developmental Biology - Animal | 1999年 / 35卷 / 5期
关键词：
1,25(OH)[!sub]2[!/sub]- dihydroxyvitamin D[!sub]3[!/sub; Bone; Fetus; MRNA; Parathyroid hormone-related peptide (PTHrP); Rat;
D O I：
10.1007/s11626-999-0074-9
中图分类号：
学科分类号：
摘要：
When fetal rat long bones are incubated in the presence of 10-8 M 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], steady-state parathyroid hormone- related peptide (PTHrP) mRNA levels are decreased. This decrease is temporary: it is observed as soon as after 3 h of exposure and reaches a nadir after 6 h. At that time, PTHrP mRNA levels are significantly lower in the experimental than in the control bones. However the inhibitory effect vanishes after 24 h, despite continuous exposure to 1,25(OH)2D3 for even 48 h. This is the first report showing that PTHrP mRNA expression can be regulated in rat fetal long bones in vitro by 1,25(OH)2D3.
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页码：296 / 298
页数：2
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