Clinical and pathological significance of N-Myc downstream-regulated gene 2 (NDRG2) in diverse human cancers

被引：0
|
作者：
Wei Hu
Yang Yang
Chongxi Fan
Zhiqiang Ma
Chao Deng
Tian Li
Jianjun Lv
Weiwei Yao
Jianyuan Gao
机构：
[1] The Fourth Military Medical University,Department of Geriatrics, Xijing Hospital
[2] The Fourth Military Medical University,Department of Biomedical Engineering
[3] The Fourth Military Medical University,Department of Thoracic Surgery, Tangdu Hospital
[4] The Fourth Military Medical University,Department of Cardiovascular Surgery, Xijing Hospital
来源：
Apoptosis | 2016年 / 21卷
关键词：
N-Myc downstream-regulated gene 2; Cancers; Clinical and pathological significance;
D O I：
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中图分类号：
学科分类号：
摘要：
Human N-Myc downstream-regulated gene 2 (NDRG2), located at chromosome 14q11.2, has been reported to be down-regulated and associated with the progression and prognosis of diverse cancers. Collectively, previous studies suggest that NDRG2 functions as a candidate tumor-suppressor gene; thus, up-regulation of NDRG2 protein might act as a promising therapeutic strategy for malignant tumors. The aim of this review was to comprehensively present the clinical and pathological significance of NDRG2 in human cancers.
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页码：675 / 682
页数：7
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