Opportunities and challenges of pluripotent stem cell neurodegenerative disease models

被引:0
|
作者
Jackson Sandoe
Kevin Eggan
机构
[1] Harvard University,Department of Molecular and Cellular Biology
[2] Harvard Stem Cell Institute,Department of Stem Cell and Regenerative Biology
[3] Harvard University,undefined
[4] The Howard Hughes Medical Institute,undefined
[5] Harvard University,undefined
来源
Nature Neuroscience | 2013年 / 16卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
The use of patient-derived stem cells for in vitro neurodegenerative disease modeling has gained much traction in recent years. In this review, the authors examine the potential caveats and pitfalls of stem cell use and highlight insights from the literature that suggest methods for overcoming these difficulties.
引用
收藏
页码:780 / 789
页数:9
相关论文
共 50 条
  • [1] Opportunities and challenges of pluripotent stem cell neurodegenerative disease models
    Sandoe, Jackson
    Eggan, Kevin
    NATURE NEUROSCIENCE, 2013, 16 (07) : 780 - 789
  • [2] Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease
    Wu, Yi-Ying
    Chiu, Feng-Lan
    Yeh, Chan-Shien
    Kuo, Hung-Chih
    OPEN BIOLOGY, 2019, 9 (01)
  • [3] Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities
    Kim, Tae Wan
    Koo, So Yeon
    Studer, Lorenz
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
  • [4] Stem Cell Challenges in the Treatment of Neurodegenerative Disease
    Feng, Zhongling
    Gao, Feng
    CNS NEUROSCIENCE & THERAPEUTICS, 2012, 18 (02) : 142 - 148
  • [5] Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease
    Jimenez-Moreno, Natalia
    Stathakos, Petros
    Caldwell, Maeve A.
    Lane, Jon D.
    CELLS, 2017, 6 (03)
  • [8] Induced pluripotent stem cells: opportunities and challenges
    Okita, Keisuke
    Yamanaka, Shinya
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2011, 366 (1575) : 2198 - 2207
  • [9] Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases
    Zhang, Xinwen
    Hu, Di
    Shang, Yutong
    Qi, Xin
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2020, 1866 (04):
  • [10] Review Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening
    Chang, Chia-Yu
    Ting, Hsiao-Chien
    Liu, Ching-Ann
    Su, Hong-Lin
    Chiou, Tzyy-Wen
    Lin, Shinn-Zong
    Harn, Horng-Jyh
    Ho, Tsung-Jung
    MOLECULES, 2020, 25 (08):