Synthesis of Isotope-labeled Aminoacids Contained in Servamycin Antibiotic

被引：0

作者：

A. Ogrel'

V. Rimavi

J. Raap

V. Shvets

机构：

[1] Moscow State Academy of Fine Chemical Processing,Leiden Institute of Chemistry, Gorlaeus Laboratories

[2] Leiden University,undefined

来源：

Russian Journal of Organic Chemistry | 2001年 / 37卷

关键词：

Enzyme; Spectroscopy; Organic Chemistry; Catalysis; Glutamine;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Approach was developed to a preparative synthesis of isotope-labeled aminoacids contained in servamycin IIB antibiotic. Glutamines labeled with 15N, 13N, and 2H were prepared in 70-80% yield starting with the corresponding labeled glutamic acids under catalysis with the glutamine synthetase enzyme. 15N-2-aminoisobutanoic acid and 15N-isovaline were obtained by Strecker method in 65 and 31% yields respectively. All compounds synthesized were identified and characterized by NMR spectroscopy.

引用

页码：475 / 479

页数：4

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