Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines

被引：0
|
作者：
Stanisław Boryczka
Wojciech Mól
Magdalena Milczarek
Joanna Wietrzyk
Ewa Bębenek
机构：
[1] Medical University of Silesia,Department of Organic Chemistry
[2] Ludwik Hirszfeld Institute of Immunology and Experimental Therapy,Department of Experimental Oncology
[3] Polish Academy of Sciences,undefined
来源：
Medicinal Chemistry Research | 2011年 / 20卷
关键词：
Acetylenic thioquinolines; (4-Chloro-2-butynyl)thioquinolines; (4-Acyloxy-2-butynyl)thioquinolines; Antiproliferative activity;
D O I：
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中图分类号：
学科分类号：
摘要：
The series of new acetylenic thioquinolines containing propargyl, 4-chloro-2-butynyl, and 4-acyloxy-2-butynyl groups have been prepared and tested for antiproliferative activity in vitro against human [SW707 (colorectal adenocarcinoma), CCRF/CEM (leukemia), T47D (breast cancer)] and murine [P388 (leukemia), B16 (melanoma)] cancer lines. Most of the obtained compounds exhibited antiproliferative activity, especially compounds 8, 12, and 21 showed the ID50 values ranging from 0.4 to 3.8 μg/ml comparable to that of cisplatin used as reference compounds.
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页码：1402 / 1410
页数：8
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