A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

被引：0

作者：

Nicole Soranzo

Tim D Spector

Massimo Mangino

Brigitte Kühnel

Augusto Rendon

Alexander Teumer

Christina Willenborg

Benjamin Wright

Li Chen

Mingyao Li

Perttu Salo

Benjamin F Voight

Philippa Burns

Roman A Laskowski

Yali Xue

Stephan Menzel

David Altshuler

John R Bradley

Suzannah Bumpstead

Mary-Susan Burnett

Joseph Devaney

Angela Döring

Roberto Elosua

Stephen E Epstein

Wendy Erber

Mario Falchi

Stephen F Garner

Mohammed J R Ghori

Alison H Goodall

Rhian Gwilliam

Hakon H Hakonarson

Alistair S Hall

Naomi Hammond

Christian Hengstenberg

Thomas Illig

Inke R König

Christopher W Knouff

Ruth McPherson

Olle Melander

Vincent Mooser

Matthias Nauck

Markku S Nieminen

Christopher J O'Donnell

Leena Peltonen

Simon C Potter

Holger Prokisch

Daniel J Rader

Catherine M Rice

Robert Roberts

Veikko Salomaa

机构：

[1] Human Genetics,Department of Twin Research and Genetic Epidemiology

[2] Wellcome Trust Sanger Institute,Department of Haematology

[3] Genome Campus,Department of Health Sciences

[4] King's College London,Department of Biostatistics and Epidemiology

[5] Institute of Epidemiology,Department of Haematology

[6] Helmholtz Zentrum München,Department of Molecular Biology

[7] German Research Center for Environmental Health,Department of Medicine

[8] University of Cambridge and National Health Service Blood and Transplant,Department of Genetics

[9] Interfaculty Institute for Genetics and Functional Genomics,Department of Medicine

[10] Ernst-Moritz-Arndt-Universität Greifswald,Haematology Department

[11] Institut für Medizinische Biometrie und Statistik,Genetics Division

[12] Universität zu Lübeck,Department of Clinical Sciences

[13] Medizinische Klinik II,Division of Cardiology, Department of Medicine

[14] Universität zu Lübeck,Cardiovascular Research Center and Cardiology Division

[15] University of Leicester,Department of Human Genetics

[16] John & Jennifer Ruddy Canadian Cardiovascular Genetics Centre,Departments of Medicine and Epidemiology

[17] University of Ottawa Heart Institute,Department of Epidemiology

[18] University of Pennsylvania,undefined

[19] Chronic Disease Prevention,undefined

[20] National Institute for Health and Welfare,undefined

[21] The Institute of Molecular Medicine,undefined

[22] University of Helsinki,undefined

[23] Center for Human Genetic Research,undefined

[24] Massachusetts General Hospital,undefined

[25] Program in Medical and Population Genetics,undefined

[26] Broad Institute of MIT and Harvard,undefined

[27] European Bioinformatics Institute,undefined

[28] King's College London,undefined

[29] Massachusetts General Hospital,undefined

[30] Harvard Medical School,undefined

[31] Harvard Medical School,undefined

[32] University of Cambridge School of Clinical Medicine,undefined

[33] Addenbrooke's Hospital,undefined

[34] Cardiovascular Research Institute,undefined

[35] MedStar Research Institute,undefined

[36] Washington Hospital Center,undefined

[37] Cardiovascular Epidemiology and Genetics,undefined

[38] Institut Municipal D'investigacio Medica and CIBER Epidemiología y Salud Pública,undefined

[39] Cambridge University Hospitals NHS Foundation Trust,undefined

[40] Section of Genomic Medicine,undefined

[41] Imperial College London,undefined

[42] South Kensington Campus,undefined

[43] Cardiovascular Sciences,undefined

[44] University of Leicester,undefined

[45] Glenfield Hospital,undefined

[46] The Center for Applied Genomics,undefined

[47] Children's Hospital of Philadelphia,undefined

[48] BHF Heart Research Centre,undefined

[49] Clinical Cardiology,undefined

[50] Leeds General Infirmary,undefined

来源：

Nature Genetics | 2009年 / 41卷

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摘要：

Nicole Soranzo and colleagues report a meta-analysis of genome-wide association datasets identifying 22 associations to 8 clinically relevant hematological traits. They also identify a long-range haplotype at 12q24 that includes variants associated with platelet counts as well as coronary artery disease and shows evidence of a selective sweep in Europeans.

引用

页码：1182 / 1190

页数：8

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[1] A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
Soranzo, Nicole
Spector, Tim D.
Mangino, Massimo
Kuehnel, Brigitte
Rendon, Augusto
Teumer, Alexander
Willenborg, Christina
Wright, Benjamin
Chen, Li
Li, Mingyao
Salo, Perttu
Voight, Benjamin F.
Burns, Philippa
Laskowski, Roman A.
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Nieminen, Markku S.
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