Mechanisms of Disease: the developmental origins of disease and the role of the epigenotype

被引：0
|
作者：
Susan E Ozanne
Miguel Constância
机构：
[1] University of Cambridge,SE Ozanne is a British Heart Foundation Lecturer in the Department of Clinical Biochemistry
[2] and M Constância is a David Phillips Research Fellow in the Laboratory of Developmental Genetics and Imprinting,undefined
[3] The Babraham Institute,undefined
[4] Cambridge,undefined
[5] UK.,undefined
来源：
Nature Clinical Practice Endocrinology & Metabolism | 2007年 / 3卷
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摘要：
Epigenetic mechanisms alter gene expression without changing the nucleotide sequence; nevertheless, they can transmit through generations of cells. This article discusses how the fetal environment might affect the epigenotype of the fetus and how this might affect subsequent development of diseases, such as diabetes, later in life and perhaps in subsequent generations.
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页码：539 / 546
页数：7
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