The Acute Effects of Postprandial Hypertriglyceridemia on Coagulation Parameters in Normal and Overweight Individuals

Postprandial hypertriglyceridemia may have a procoagulant effect and cause an activation of coagulation system. The measurement of postprandial triglyceride concentrations and coagulation parameters may give additional useful data besides the fasting measurement. Thus, we investigated the acute effects of hypertriglyceridemia after the meal in normal and overweight individuals. Fourteen overweight (Group I) and sixteen normal weight (Group II) voluntary participants were given fat-rich meal (700 kcal). Blood samples were obtained at fasting, 3rd and 6th hours. In both groups, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglyceride (TG), fibrinogen, prothrombin time (PT), activated partial thromboplastin time, factor VII (FVII), factor IX (FIX), protein C and, protein S activities were measured. As might be expected, TG levels were higher in the postprandial state than the fasting state in both groups and also Group I subjects had higher levels rather than Group II at all states. One of our important finding finding was that PT levels were shorter in Group I at the fasting, postprandial 3rd and 6th hours than Group II (P = 0.007, P = 0.033, P = 0.047 respectively). Moreover, FVII and FIX activities were found as higher in Group I at the postprandial 3rd hour (P = 0.047, P = 0.008 respectively). In conclusion, the high activities of FVII and FIX and short PT levels may predispose to thrombosis in Group I, especially at postprandial states. © 2014, Association of Clinical Biochemists of India.