Pathogenesis of ankylosing spondylitis — recent advances and future directions

被引：0
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作者：
Vidya Ranganathan
Eric Gracey
Matthew A. Brown
Robert D. Inman
Nigil Haroon
机构：
[1] Krembil Research Institute,Department of Immunology
[2] University Health Network,Department of Medicine, Division of Rheumatology
[3] University of Toronto,undefined
[4] Institute of Health and Biomedical Innovation,undefined
[5] Queensland University of Technology,undefined
[6] Translational Research Institute,undefined
[7] University of Toronto,undefined
[8] Toronto Western Hospital,undefined
来源：
Nature Reviews Rheumatology | 2017年 / 13卷
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摘要：
More than 100 genetic loci have been associated with ankylosing spondylitis (AS), but together they explain less than 30% of AS heritabilityMultiple genes involved in antigen processing and presentation are associated with ASInvestigation into the cellular sources and regulation of IL-17 production is crucial to understanding the pathogenesis of ASCells involved in type 3 immunity produce IL-17 and include innate lymphoid cells and γδ T cellsGiven the efficacy of the anti-IL-17 monoclonal antibody secukinumab in the treatment of AS, other therapies targeting type 3 immunity could also be effective
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页码：359 / 367
页数：8
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