Stem cell therapy for human neurodegenerative disorders–how to make it work

被引：0
|
作者：
Olle Lindvall
Zaal Kokaia
Alberto Martinez-Serrano
机构：
[1] Laboratory of Neurogenesis and Cell Therapy,Department of Clinical Neuroscience
[2] Section of Restorative Neurology,Department of Clinical Neuroscience
[3] Wallenberg Neuroscience Center,undefined
[4] University Hospital,undefined
[5] Lund Strategic Research Center for Stem Cell biology and Cell Therapy,undefined
[6] Laboratory of Neural Stem Cell Biology,undefined
[7] Section of Restorative Neurology,undefined
[8] University Hospital,undefined
[9] Human Neural Stem Cell Biology and Gene Therapy Group,undefined
[10] Center of Molecular Biology Severo Ochoa,undefined
[11] Autonomous University of Madrid,undefined
[12] Cantoblanco,undefined
来源：
Nature Medicine | 2004年 / 10卷
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摘要：
Recent progress shows that neurons suitable for transplantation can be generated from stem cells in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. These findings raise hope for the development of stem cell therapies in human neurodegenerative disorders. Before clinical trials are initiated, we need to know much more about how to control stem cell proliferation and differentiation into specific phenotypes, induce their integration into existing neural and synaptic circuits, and optimize functional recovery in animal models closely resembling the human disease.
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页码：S42 / S50
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