Electrochemical determination of isoprenaline using a graphene-modified glassy carbon electrode

The electrochemical determination of isoprenaline (IP) using a graphene-modified glassy carbon electrode (GME) was investigated by cyclic voltammetry. The results showed that the GME exhibited excellent electrochemical activity towards IP in pH 4.0 phosphate buffer solution (PBS). The reduction peak current (ipc) of IP was linearly proportional to its concentration in the range of 2.1 × 10−7–1.0 × 10−5 mol L−1 and 1.0 × 10−5–1.0 × 10−4 mol L−1, with the linear regression equations as ipc1(A) = −2.31 × 10−6 + 6.96c (c/moles per liter), R1 = 0.9982 and ipc2 = 6.00 × 10−5 − 0.49c (c/moles per liter), R2 = 0.9971, respectively, and a detection limit of 6.4 × 10−8 mol L−1. This method is of simplicity, rapidity, and high sensitivity and provides a practicable solution for the selective determination of IP in the presence of uric acid and ascorbic acid. The method has been successfully applied to IP sample analysis.