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Acute and chronic infections with nonprimate hepacivirus in young horses

被引：0
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作者：
Theresa Gather
Stephanie Walter
Stephanie Pfaender
Daniel Todt
Karsten Feige
Eike Steinmann
Jessika M. V. Cavalleri
机构：
[1] University of Veterinary Medicine Hannover,Clinic for Horses
[2] Foundation,Institute for Experimental Virology
[3] TWINCORE Centre for Experimental and Clinical Infection Research,undefined
来源：
Veterinary Research | / 47卷
关键词：
High Viral Load; Sampling Time Point; Maternal Antibody; Mild Elevation; Field Infection;
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摘要：
The recently discovered nonprimate hepacivirus (NPHV) naturally infects horses and is the closest known homolog of hepatitis C virus to date. Within a follow-up study acute field infections were monitored in four young Thoroughbred horses until the ages of 12–13 months. Serum samples were analyzed for the presence of NPHV RNA and anti-NPHV NS3 antibodies and liver specific parameters were evaluated. The four young horses were not able to clear infection, but remained chronically infected for the entire monitored time period despite the presence of NPHV specific antibodies.
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