NMDA receptor–dependent metaplasticity at hippocampal mossy fiber synapses

被引:0
|
作者
Nelson Rebola
Mario Carta
Frederic Lanore
Christophe Blanchet
Christophe Mulle
机构
[1] University de Bordeaux,
[2] Interdisciplinary Institute for Neuroscience,undefined
[3] Centre National de la Recherche Scientifique (CNRS),undefined
[4] Interdisciplinary Institute for Neuroscience,undefined
[5] UMR 5297,undefined
[6] Bordeaux,undefined
[7] France.,undefined
来源
Nature Neuroscience | 2011年 / 14卷
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摘要
Although they contain NMDA receptors, hippocampal mossy fiber synapses onto CA3 pyramidal cells have been reported to lack conventional NMDA receptor–dependent LTP of AMPA EPSCs. Here, the authors find that LTP of NMDA receptors serves as a metaplastic switch, making mossy fiber synapses competent to express NMDA receptor–dependent LTP of AMPA EPSCs.
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页码:691 / 693
页数:2
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