Dupilumab elicits a favorable response in type-2 inflammatory comorbidities of severe atopic dermatitis

被引：4
|
作者：
Nettis E. [1 ]
Masciopinto L. [1 ]
Di Leo E. [2 ]
De Candia N. [3 ]
Albanesi M. [1 ]
Di Bona D. [1 ]
Quaranta N. [3 ]
Macchia L. [1 ]
机构：
[1] Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Policlinico Di Bari, Bari
[2] Section of Allergy and Clinical Immunology, Unit of Internal Medicine – “F. Miulli” Hospital, Acquaviva Delle Fonti, Bari
[3] Department of Neuroscience and Sensory Organs, Otolaryngology Unit, University of Bari Aldo Moro, Policlinico Di Bari, Bari
来源：
Clinical and Molecular Allergy | / 19卷 / 1期
关键词：
Asthma; Monoclonal antibody; Nasal polyps; Precision medicine; Rhinoconjuctivitis;
D O I：
10.1186/s12948-021-00144-x
中图分类号：
学科分类号：
摘要：
Background: This case is the first report describing rapid, successful treatment of severe atopic dermatitis (AD) and comorbid type-2 inflammatory diseases in the same patient, with dupilumab treatment, with no side-effects. Case presentation: We report on effects of dupilumab in a patient with severe AD, a long-standing history of a mild, perennial allergic rhino-conjunctivitis, moderate asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). Conclusions: Patients suffering from AD, asthma, allergic rhinitis and CRSwNP may be eligible for dupilumab single treatment that is possibly advantageous also from the pharmaco-economic standpoint. © 2021, The Author(s).
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