CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview

被引：0

作者：

Mohamad Mohty

Remy Dulery

Jordan Gauthier

Florent Malard

Eolia Brissot

Mahmoud Aljurf

Ali Bazarbachi

Christian Chabanon

Mohamed A. Kharfan-Dabaja

Bipin N. Savani

He Huang

Saad S. Kenderian

Miguel-Angel Perales

Ibrahim Yakoub-Agha

Arnon Nagler

机构：

[1] Sorbonne Université,Service d’Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint

[2] INSERM UMRs 938,Antoine

[3] Fred Hutchinson Cancer Research Center,Clinical Research Division, Integrated Immunotherapy Research Center

[4] University of Washington,Department of Medicine, Division of Medical Oncology

[5] King Faisal Specialist Hospital & Research Centre,Oncology Center

[6] American University of Beirut,Department of Internal Medicine

[7] Inserm CBT-1409 & Aix-Marseille Université,Institut Paoli

[8] Blood and Marrow Transplantation Program,Calmettes

[9] Division of Hematology-Oncology,Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine

[10] Mayo Clinic,Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine

[11] Vanderbilt University Medical Center and Veterans Affairs Medical Center,Division of Hematology, Department of Medicine

[12] Institute of Hematology,Adult Bone Marrow Transplantation Service, Department of Medicine

[13] Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy,The Chaim Sheba Medical Center, Tel

[14] Zhejiang University,Hashomer, Affiliated with the Sackler School of Medicine

[15] Mayo Clinic,undefined

[16] Weill Cornell Medical College,undefined

[17] Memorial Sloan Kettering Cancer Center,undefined

[18] CHU de Lille,undefined

[19] LIRIC,undefined

[20] INSERM U995,undefined

[21] Université de Lille,undefined

[22] Tel-Aviv University,undefined

来源：

Bone Marrow Transplantation | 2020年 / 55卷

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摘要：

The goal of this review is to firstly address the concept of chimeric antigen receptor T-cell (CAR T-cell) therapy and where it fits in the evolving landscape of the management of patients with refractory/relapsed diffuse large B-cell lymphoma. The recognition of the indications for CAR T-cell therapy for patients with aggressive B-cell lymphoma will be discussed, including a review of the algorithms and selection criteria for CAR T-cell therapy and finally, the role of bridging therapy and the timing of CAR T-cell therapy in augmenting chances of a successful outcome.

引用

页码：1525 / 1532

页数：7

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