Synergism of sulfur-containing phenol (SO-4) with mexidol, α-tocopherol, and phospholipids

The antioxidant activity of mexidol (a 3-hydroxypyridine derivative) and sulfur-containing sterically hindered phenol (SO-4) was studied in an initiated oxidation model system in comparison α-tocopherol and dibunol. A linear dependence of the oxidation inhibition effect on the concentration of both substances is established. The antioxidants are capable of destroying hydroperoxides and inhibiting their accumulation. The joint inhibiting action of SO-4 in combination with mexidol, α-tocopherol and phospholipids was observed for the first time. © 2006 Springer Science+Business Media, Inc.