Differential Resistance to Oxidants and Production of Hydrolytic Enzymes in Candida albicans

被引：0
|
作者：
Maxwel A. Abegg
Rodrigo Lucietto
Paulo V. G. Alabarse
Marcus F. A. Mendes
Mara Silveira Benfato
机构：
[1] Universidade Paranaense,Programa de Pós
[2] UNIPAR,Graduação em Biologia Celular e Molecular, PPGBCM
[3] Universidade Federal do Rio Grande do Sul,Departamento de Biofísica, IBIO
[4] UFRGS,undefined
[5] Universidade Federal do Rio Grande do Sul,undefined
[6] UFRGS,undefined
[7] Universidade Federal do Rio Grande do Sul,undefined
[8] UFRGS,undefined
来源：
Mycopathologia | 2011年 / 171卷
关键词：
Oxidative stress; Protease; Phospholipase;
D O I：
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中图分类号：
学科分类号：
摘要：
Resistance to the toxic effects of reactive oxygen species produced by phagocytes and production of hydrolytic enzymes are important aspects of Candida albicans virulence. In this report, we compared twelve C. albicans isolates for their in vitro capacity to resist oxidants—hydrogen peroxide, menadione and paraquat; and to produce hydrolytic enzymes—phospholipase and protease. Different C. albicans isolates showed different degrees of resistance to oxidants as well as differences in production of hydrolytic enzymes. Resistance to oxidative stress did not correlate with production of hydrolytic enzymes. This reinforces the view that C. albicans differentially regulates the expression of virulence factors in response to local environmental conditions.
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页码：35 / 41
页数：6
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