BAP1 methylation: a prognostic marker of uveal melanoma metastasis

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作者：
Mathieu F. Bakhoum
Ellis J. Curtis
Michael H. Goldbaum
Paul S. Mischel
机构：
[1] Yale University School of Medicine,Department of Ophthalmology and Visual Science
[2] University of California San Diego,Department of Ophthalmology
[3] University of California San Diego,School of Medicine
[4] Stanford University School of Medicine,Department of Pathology
[5] Stanford University,ChEM
来源：
npj Precision Oncology | / 5卷
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摘要：
Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous tumors. Here, we show that assessment of BAP1 methylation is an accurate and readily clinically actionable assay to accurately identify high-risk uveal melanoma patients.
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